Follow the Brenner motorway (A22) until Egna-Ora/Neumarkt-Auer. Take the direction of Val di Fiemme / Val di Fassa. After about 40 km you will reach Moena.
Get off at the station of Trento on the Brenner route. At the station you will find the bus to Moena.
The nearest airports are in Bolzano (65 km) and Verona (180 km).